Summary: Long-lived reservoirs of persistent HIV are a major barrier to a cure.CD4+ hematopoietic stem and progenitor cells (HSPCs) have the capacity for lifelong rme ufx iii survival, self-renewal, and the generation of daughter cells.Recent evidence shows that they are also susceptible to HIV infection in vitro and in vivo.Whether HSPCs harbor in
IntroductionPhage WO represents the sole bacteriophage identified to infect Wolbachia, exerting a range of impacts on the ecological dynamics and evolutionary trajectories of its host.Given ranchy doodle the extensive prevalence of Wolbachia across various species, phage WO is likely among the most prolific phage lineages within arthropod populatio
Abstract Covalent willy wonka book week costume drugs can achieve high potency with long dosing intervals.However, concerns remain about side-effects associated with off-target reactivity.Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, p